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Laurentiu Lupu MD's avatar

The line I keep returning to is "Of course they did." I appreciated that you gave the explanation before the reader had to reach for one.

Internal mammary artery ligation for angina had something the saline injection did not: a plausible mechanism and a real operation behind it. Patients reported less angina afterwards. A sham arm was what showed that the reported improvement was no greater with ligation than without it.

What stayed with me is how much depended on someone deciding to build that control group. Until then, the mechanism and the patient reports could easily seem to point in the same direction. It made me wonder how often an equivalent decision gets made in aesthetics.

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